WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Hel a 6
Allergen source: Major taxonomic group: Plantae Eudikotyledons
Order: Asterales
Species: Helianthus annuus (Sunflower)
NCBI Taxomony ID: 4232
Biochemical name:Pectate Lyase
Allergenicity:Subjects used in these tests have airway allergy, presumably from sunflower pollen. Six negative controls were used in serum IgE tests and Skin Prick Tests (SPT). Fifty three patients from Kolkata, India were tested by serum IgE binding to purified natural protein, with 19 having positive binding. Seventy five subject were tested by SPT with 28 positive. Basophil activation was tested using 12 subjects, four of them gave positive responses. The three controls to basophil tests were negative. The protein was purified by chromatography and gel electrophoresis, and found to be 95% pure. LC-mass spectrometry identified five peptides matching protein accession number OTF85892.1 in teh GenBank Protein database. A publication is in progress.
Allergenicity reference:PubMed:33214682
Route of allergen exposure:Airway
Date Created:11-12-2017
Last Updated:2021-08-27 18:03:32
Submitter Info:
Name:Nandini Ghosh, Swati Gupta Bhattacharya
Institution:Bose Institute, Div. of Plant Biology
City:Kolkata, India,
Submission Date:2017-08-08


Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Hel a 6.0101 OTF85892A0A251RNJ1