WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Aed a 11
Allergen source: Major taxonomic group: Animalia Arthropoda
Order: Diptera
Species: Aedes aegypti (Yellow fever mosquito)
NCBI Taxomony ID: 7159
Biochemical name:Lysosomal aspartic protease
Allergenicity:15 subjects with airway and/or dermal allergic reactions upon exposure to mosquito bites or Case history of mosquito allergy (bites and/or inhalation of insect parts) from subjects living in the Caribbean island of Martinique with asthma and/or rhinitis and specific IgE to mosquito extract. Proteins of defatted, freeze dried mosquitoes, with proteins separated on 2D gels and immunoblotted with six individual sera Abstract presented at EAACI Barcelona, 2015. IgE binding spots were identified by mass LC/MS-MS of trypsinized gel spots. Lysosomal aspartic protease bound IgE from 3 of 6 subjects.
Allergenicity reference:PubMed:28235135
Route of allergen exposure:Injection
Created:2016-03-02 12:00:00
Last Updated:2019-06-28 17:43:43
Submitter Info:
Name:Jose F. Cantillo
Institution:Instituto de Investigaciones Inmunologicas-Universidad de Cartagena
City:Cartagena, Colombia
Submission Date:2015-12-16


Posted: 12 Mar 2016

Presentation of new allergens of Aedes aegypti (Aed a 4-8) in oral abstract session of the EAACI, Barcelona, Spain, 2015; abstract in Allergy, v70, abstr # 133. The work done for the identification and characterization of this allergen were made by:
Jose F. Cantillo, Leonardo Puerta and Enrique Fernandez-Caldas. This was originally posted in December 2015 as Aed e 4; but a decision was made that it should have received a different designation since another group (Z Peng) published a different protease as Aed a 4 earlier and it was in a number of publications. Therefore this entry was moved to Aed a 11 on 12 March, 2016

Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Aed a 11.0101XM_001657506.1XP_001657556.1Q03168