Allergen Details:
| Allergen name: | Aed a 4 |
|---|---|
| Allergen source: |
Major taxonomic group: Animalia Arthropoda Order: Diptera Species: Aedes aegypti (Yellow fever mosquito) NCBI Taxomony ID: 7159 |
| Biochemical name: | alpha-glucosidase |
| MW(SDS-PAGE): | 67 kDa |
| Allergenicity: | Subjects were allergic to mosquito bites. 13 of 13 were positive to challenge bites of mosquito, Aedes aegypti, 18 controls were negative. 6 of 13 subjects were IgE binding positive to recombinant Aed a 4 by ELISA, 18 controls were negative. ELISA and ELISA inhibition were performed with native (extract of head and thorax) and recombinant Aed a 4 produced in baculovirus insect cell line. |
| Allergenicity reference: | PubMed:17620829 PubMed:18220995 PubMed:25661054 |
| Route of allergen exposure: | Injection |
| Created: | 2016-03-13 12:00:00 |
| Last Updated: | 2019-07-20 18:26:53 |
| Submitter Info: | |
| Name: | Zhikang Peng |
| Institution: | University of Manitoba, Dept. of Pediatrics and Child Health |
| City: | Winnipeg, Canada |
| Email: | zpeng@umanitoba.ca |
| Submission Date: | 2016-02-22 |
Comments
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Aed a 4.0101 | M30442.1 | P13080 |
On 30 December, 2015 a different protease from mosquito was entered as Aed a 4, from Jose Cantillo. In a review of information in March, 2016 a decision was made that the designation Aed a 4 should below to a protease identified in 2001 by Z Peng. The Cantillo entry became Aed a 11. The Peng protein and information was input on 12 March, 2016 as Aed a 4.0101 by REG