WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Aed a 4
Allergen source: Major taxonomic group: Animalia Arthropoda
Order: Diptera
Species: Aedes aegypti (Yellow fever mosquito)
NCBI Taxomony ID: 7159
Biochemical name:alpha-glucosidase
Allergenicity:Subjects were allergic to mosquito bites. 13 of 13 were positive to challenge bites of mosquito, Aedes aegypti, 18 controls were negative. 6 of 13 subjects were IgE binding positive to recombinant Aed a 4 by ELISA, 18 controls were negative. ELISA and ELISA inhibition were performed with native (extract of head and thorax) and recombinant Aed a 4 produced in baculovirus insect cell line.
Allergenicity reference:PubMed:17620829PubMed:18220995PubMed:25661054
Route of allergen exposure:Injection
Date Created:22-06-2016
Last Updated:2019-07-20 18:26:53
Submitter Info:
Name:Zhikang Peng
Institution:University of Manitoba, Dept. of Pediatrics and Child Health
City:Winnipeg, Canada
Submission Date:2016-02-22


Posted: 12 Mar 2016

On 30 December, 2015 a different protease from mosquito was entered as Aed a 4, from Jose Cantillo. In a review of information in March, 2016 a decision was made that the designation Aed a 4 should below to a protease identified in 2001 by Z Peng. The Cantillo entry became Aed a 11. The Peng protein and information was input on 12 March, 2016 as Aed a 4.0101 by REG

Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Aed a 4.0101M30442.1P13080