WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Per a 12
Allergen source: Major taxonomic group: Animalia Arthropoda
Order: Blattodea
Species: Periplaneta americana (American cockroach)
NCBI Taxomony ID: 6978
Biochemical name:Chitinase
Allergenicity:Sera from 30 of 40 (63.8%) patients reacted to Per a 12 on immunoblots. ELISA inhibition of serum IgE reactivity to the cockroach midgut extract (CME) using purified Per a 12 was significant (40%). Nine of 15 (60%) cockroach-allergic patients had positive SPT reactions to Per a 12. In comparison with healthy control, Per a 12 at 1.0 g/ml induced approximately up to 5-fold increase in the number of CD63 and CCR3 double-positive cells following incubating it with PBMC from patients with cockroach allergy
Allergenicity reference:PubMed:26361742
Route of allergen exposure:Airway
Created:2015-06-02 12:00:00
Last Updated:2024-07-09 18:09:43
Submitter Info:
Name:Su An
Institution:Kunming Institute of Zoology, Chinese Academy of Sciences
City:Kunming, China
Submission Date:2015-05-05


Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Per a 12.0101KR019686AKH04311