Allergen Details:
| Allergen name: | Ara h 15 |
|---|---|
| Allergen source: |
Major taxonomic group: Plantae Eudikotyledons Order: Fabales Species: Arachis hypogaea (Peanut, groundnut) NCBI Taxomony ID: 3818 |
| Obsolete name: | Oleosin 3 |
| Biochemical name: | Oleosin |
| MW(SDS-PAGE): | 17 kDa |
| Allergenicity: | 15 of 33 subjects with peanut allergy had demonstrable IgE binding to this protein (based on communication with submission) |
| Allergenicity reference: | PubMed:25860789 PubMed:28342912 |
| Route of allergen exposure: | Food |
| Created: | 2015-05-02 12:00:00 |
| Last Updated: | 2020-05-14 17:16:37 |
| Submitter Info: | |
| Name: | Uta Jappe, Christian Schwager, Skadi Kull, Susanna Krause, Frauke Schocker, Arnd Petersen, Wolf-Meinhard Becker |
| Institution: | Research Center Borstel, Division of Clinical and Molecular Allergology, Research Center Borstel, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL) |
| City: | Borstel, Germany |
| Email: | ujappe@fz-borstel.de |
| Submission Date: | 2015-03-27 |
Comments
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Ara h 15.0101 | AY722696 | AAU21501 | Q647G3 |
From submission: Results obtained from N-terminal sequencing and peptide mass fingerprinting of the protein gave reliable evidence that this proteins refers to the amino acid sequence from Uniprot Q647G3, a peanut oleosin. Therefore, a new allergen name is suggested. Sequence identity to the registered peanut oleosins Ara h 10 and Ara h 11 is below 48%. In addition, the sequence identity to the submitted allergen Ara h 14 is below 30 % (Alignments were performed using ClustalW2, https://www.ebi.ac.uk/Tools/msa/clustalw2).