WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Asc s 13
Allergen source: Major taxonomic group: Animalia Nematoda
Order: Ascaridida
Species: Ascaris suum (Pig roundworm)
NCBI Taxomony ID: 6253
Biochemical name:Glutathione S-transferase
Allergenicity:20 of 29 Ascaris ImmunoCAP positive subjects showed IgE binding to GST by ELISA; 12 of 91 non-asthmatic controls were positive by ELISA to GST in vitro IgE binding; 42 of 215 Asmthmatic subjects were positive to GST by ELISA; 3 of 10 asthmatics tested with recombinant GST by Skin Prick test were positive with at least 3mm diameter wheal
Allergenicity reference:PubMed:24223794
Route of allergen exposure:Food
Created:2014-09-08 12:00:00
Last Updated:2019-07-11 23:04:42
Submitter Info:
Name:Luis Caraballo
Institution:University of Cartagena, Institute for Immunological Research
City:Cartagena, Columbia
Submission Date:2014-08-23


Posted: 09 Sep 2014

Recombinant Glutathione transferase (GST) from Ascaris suum and natural GST from Ascaris lumbricoides were used in tests of IgE binding in subjects sensitized to Ascaris extract. Some publications suggest that these two species are one, based on genetics and also proven hybridization. There is some cross reactivity to mite and cockroach GST and this protein.

Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Asc s 13.0101X75502.1CAA53218P46436