WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Ani s 13
Allergen source: Major taxonomic group: Animalia Nematoda
Order: Ascaridida
Species: Anisakis simplex (Herring worm)
NCBI Taxomony ID: 6269
Biochemical name:Hemoglobin
Allergenicity:Twenty eight of 44 case-history positive subjects diagnosed with Gastro-allergic Anisakiasis or Anisakis sensitization associated chronic urticaria, had demonstrable IgE binding to the protein by hemoglobin-specific capture ELISA.
Allergenicity reference:PubMed:25683373
Route of allergen exposure:Food
Date Created:21-07-2014
Last Updated:2019-07-03 18:54:30
Submitter Info:
Name:Juan Gonzalez-Fernandez
Institution:Universidad Complutense de Madrid
City:Madrid, Spain
Submission Date:2014-07-21


Posted: 29 Mar 2015

Manuscript now available as pre-print,available online. PUBMID 25683373.
Submitted pre-publication. Publication of the antibody used to capture the hemoglobin is: Nieuwenhuizen NE, Meter JM, Horsnell WG, Hoving JC, Fick L et al. (2013) A cross-reactive monoclonal antibody to Nematode Haemoglobin Enhances Protective Immune Responses to Nippostrongylus brasiliensis. PLoS Negl Trop Dis 7(8):e2395. Sequence confirmed 93% with MS/MS. Also, nucleotide sequence determined. PCR cloned Sequence reference 24009787 Lopata et al.
Allergenicity reference as a Congress abstract. Cuellar C, Gonzalez-Fernandez J, Rodero M, Valls A, de Frutos C, Daschner A, Nieuwenhuizen N. La Hemoglobina de Anisakis simplex: factores que influyen sobre su reconcimiento. 2013. XVIII Congreso de la Sociedad Espanola de Parasitologia.

Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Ani s 13.0101JX860676.1AFY98826K9USK2