ALLERGEN NOMENCLATURE
WHO/IUIS Allergen Nomenclature Sub-Committee

Financial contributions from IUIS, EAACI, and AAAAI

Member Login

Allergen Details:

Allergen name: Ara h 12
Allergen source: Major taxonomic group: Plantae Eudikotyledons
Order: Fabales
Species: Arachis hypogaea (Peanut, groundnut)
NCBI Taxomony ID: 3818
Biochemical name:Defensin
MW(SDS-PAGE):8 kDa (reducing), 12 kDa (non-reducing), 5.184 kDa (mass)
Allergenicity:Four peanut allergic subjects with clear clinical histories and high IgE by ImmunoCAP to peanut had demonstrable IgE binding to non-reduced defensins. BAT was positive for a few subjects to a mixture of Ara h 12 and Ara h 13.
Allergenicity reference:PubMed:26037551
Route of allergen exposure:Food
Created:2012-08-27 12:00:00
Last Updated:2024-06-28 18:28:31
Submitter Info:
Name:Arnd Petersen; Sandra Rennert; Wolf-Meinhard Becker; Susanne Krause; Thomas Gutsmann; Buko Lindner; Uta Jappe
Institution:Research Center Borstel, Division of Clinical and Molecular Allergology, Research Center Borstel, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL)
City:Borstel, Germany
Email:ujappe@fz-borstel.de
Submission Date:2012-07-03

Comments

Posted: 23 Dec 2015

Communicated with Uta Jappe a number of times. The publication in JACI 2015 is quite good (Petersen). However, the EST predicts a longer protein and the MW in the publication suggests that a longer sequence of ~ 8kDa is present in the extract. The proteins are NOT very soluble in PBS and most extracts miss them.

Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Ara h 12.0101EY396089  B3EWP3