Allergen Details
| Allergen name: | Hum j 1 |
|---|---|
| Allergen source: |
Major taxonomic group: Plantae Eudikotyledons Order: Rosales Species: Humulus japonicus (Japanese hop) NCBI Taxomony ID: 3485 |
| Molecular mass: | 10 kDa |
| Allergenicity: | Twenty-two H. japonicus allergic subjects from Korea (72%) showed IgE reactivity to proteins of 10 kDa on immunoblots. In a Chinese study, 11 of 14 sera (79%) from H. japonicus-allergic patients (symptoms in late summer + positive ImmunoCAP to H. japonicus + positive SPT) had IgE specific to purified nHum j 1 and rHum j 1.0101 (expressed in E. coli) as determined by ELISA. |
| Allergenicity reference: | PubMed:10457112 PubMed:40822751 PubMed:40625753 |
| Route of allergen exposure: | Airway |
| Created: | 2006-11-03 12:00:00 |
| Last Updated: | 2025-09-04 16:11:39 |
| Submitter Info: | |
| Name: | Ji-Fu Wei; Jin-Lyu Sun |
| Institution: | The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research; State Key Laboratory of Complex Severe and Rare Diseases, PUMCH, CAMS |
| City: | Nanjing, China; Beijing, China |
| Email: | weijifu@hotmail.com; sunjinlv@pumch.cn |
| Submission Date: | 2025-05-27 |
Comments
Table of Isoallergens
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| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Hum j 1.0101 | PV650652 | XTQ06061 |
The sequence previously recorded with Hum j 1.0101 (nucleotide: AY335187, protein: AAP94213, UniProt: Q7XBE3) was deleted. That sequence did not correspond with the N-terminal sequence originally obtained by Park and colleagues in 1999, and no publication was associated with that sequence. It was replaced by the sequence identified by Wei and coworkers, published in 2025, which corresponds with the original N-terminus.
Christian Radauer, science co-chair of the WHO/IUIS Allergen Nomenclature Sub-Committee