ALLERGEN NOMENCLATURE
WHO/IUIS Allergen Nomenclature Sub-Committee

Financial contributions from IUIS, EAACI, and AAAAI

Member Login

Allergen Details

Allergen name: Cand a 1
Allergen source: Major taxonomic group: Fungi Ascomycota
Order: Saccharomycetales
Species: Candida albicans (Common yeast)
NCBI Taxomony ID: 5476
Biochemical name:Alcohol dehydrogenase
MW(SDS-PAGE):40 kDa
Allergenicity:Of 30 asthmatic patients with a positive skin test and RAST to C.albicans, 23 (77%) showed serum IgE binding to a 40 kD component on an immunoblot of C.albicans extract. - This 40 kD protein was cloned and identified as Cand a 1. IgE binding to both natural and rCand a 1 was demonstrated on immunoblot and in ELISA (medline 92136159).
Allergenicity reference:PubMed:2665907
Route of allergen exposure:Airway
Created:2003-09-01 12:00:00
Last Updated:2019-07-20 07:50:40
Submitter Info:
Name:
Institution:
City:
Email:
Submission Date:

Comments

Posted: 29 Oct 2014

Note the allegenicity in Shen et al., 1989, Clin Exp Allergy used immunoblots of extracts to with 30 allergic sera to identify 77% + IgE binding to a 40 kDa protein (Fig 2). The sequencing paper (Shen et al., 1991, Clin Exp Allergy) shows partial cloned sequence of Cand a 1 that matches a portion of their 350 aa sequence in locus CAA57342.1. So evidence is not against purified protein. REG

Table of Isoallergens

Click on the arrows to show the details of individual isoallergens, click on +/- to show/hide the details of all isoallergens.

Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Cand a 1.0101X81694CAA57342P43067