WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Act d 6
Allergen source: Major taxonomic group: Plantae Eudikotyledons
Order: Ericales
Species: Actinidia deliciosa (Green kiwi fruit)
NCBI Taxomony ID: 3627
Biochemical name:Pectin methylesterase inhibitor
Allergenicity:IgE prevalence: 72% of 50 kiwi allergic patients
Allergenicity reference:PubMed:10880981
Route of allergen exposure:Food
Created:2007-12-18 12:00:00
Last Updated:2020-08-28 01:45:22
Submitter Info:
Submission Date:2003-03-01


Posted: 28 Aug 2020

UPDATED 28 Aug 2020. There are three papers relating to IgE binding, but they do not directly show sequence identity of the protein. An earlier paper does. It appears it is a real allergen of uncertain importance

Although we (IUIS) list pectin methylesterase inhibitor as allergen Act d 6, with a comment of 72% prevalence of IgE binding by kiwi allergic subjects, the is no record of such a publication and the IUIS records are incomplete. As reported by Bublin et al., 2011, Clin Exp Allergy 41:129-136, they did not detect any individual serum sample as having specific IgE binding to Act d 6 using sera from approximately 200 kiwi allergic subjects. Therefore the relevance of this protein as an allergen is questioned. 10 Sept. 2014 REG

THere is a series of papers claiming to have used Act d 6, without verification of sequence identity. They tie back to the sequence by Camardella et al., 2000. Some papers few matches, others claim up to 50% of kiwi allergic subjects have IgE

Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Act d 6.0101AB091088.1BAC54964P833261XG2