WHO/IUIS Allergen Nomenclature Sub-Committee

Financial contributions from IUIS, EAACI, and AAAAI

Member Login

Allergen Details:

Allergen name: Cry j 3
Allergen source: Major taxonomic group: Plantae Pinopsida
Order: Cupressales
Species: Cryptomeria japonica (Sugi, Japanese cedar)
NCBI Taxomony ID: 3369
Biochemical name:Thaumatin-like protein (pathogenesis-related protein PR-5)
Allergenicity:One hundred patients with allergy to Japanese cedar pollen, diagnosed based on typical symptoms and specific IgE (ImmunoCAP class >= 2), were tested. Of those, 27 sera contained IgE specific to highly purified natural Cry j 3. The allergen could activate basophils from a Cry j 3-sensitized patient in a histamine release assay.
Allergenicity reference:PubMed:17441795
Route of allergen exposure:Airway
Date Created:2023-12-14
Last Updated:2023-12-14 14:54:52
Submitter Info:
Name:Masahiro Sakaguchi
Institution:Institute of Tokyo Environmental Allergy
City:Tokyo, Japan
Submission Date:2023-09-14


Posted: 14 Dec 2023

The N-terminal 13 residues of nCry j 3 were determined by Edman sequencing (see allergenicity reference). This sequence corresponds to "Cry j 3.8" isolated from pollen mRNA by the submitter (nucleotide acc. no. AB254807) but also to 8 other sequences identified in the Cryptomeria japonica genome with 95-96% identical amino acid sequences. Hence, no isoallergen record was added to this entry.

Christian Radauer, science co-chair

Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB