Allergen Details:
| Allergen name: | Art si 14 |
|---|---|
| Allergen source: |
Major taxonomic group: Plantae Eudikotyledons Order: Asterales Species: Artemisia sieversiana (Sieversian wormwood) NCBI Taxomony ID: 205378 |
| Biochemical name: | Fructose bisphosphate aldolase |
| MW(SDS-PAGE): | 38 kDa |
| Allergenicity: | In an IgE dot-blot, natural Art si 14 as well as recombinant Art si 14.0101, produced in E. coli, bound IgE from 10 of 20 sera (50%) from Artemisia pollen allergic patients (symptoms: allergic rhinitis and/or asthma; ImmunoCAP class >= 3 with A. vulgaris ImmunoCAP). Nine of the ten dot-blot-positive sera also bound both allergens in IgE Western blot. In an IgE-ELISA, 50 of 87 sera (57%) from Artemisia pollen allergic patients had IgE to rArt si 14.0101. IgE ELISA inhibitions with a pool of Art si 14-sensitized sera showed partial inhibition of IgE binding to A. sieversiana pollen extract by natural and recombinant Art si 14 as well as a high extent of cross-reactivity with Art an 14. In a BAT assay, 3 of 3 Art si 14-sensitized patients reacted with rArt si 14. |
| Route of allergen exposure: | Airway |
| Created: | 2022-10-17 16:47:34 |
| Last Updated: | 2022-10-17 17:08:37 |
| Submitter Info: | |
| Name: | Ji-Fu Wei, Jin-Lyu Sun |
| Institution: | Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University; State Key Laboratory of Complex Severe and Rare Diseases, PUMCH, CAMS |
| City: | Nanjing, China and Beijing, China |
| Email: | weijifu@hotmail.com, sunjinlv@pumch.cn |
| Submission Date: | 2022-10-07 |
Comments
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Art si 14.0101 | MW790924 | UUH54329 | 7EFS |