Allergen Details:
| Allergen name: | Cor a 15 |
|---|---|
| Allergen source: |
Major taxonomic group: Plantae Eudikotyledons Order: Fagales Species: Corylus avellana (Hazelnut) NCBI Taxomony ID: 13451 |
| Biochemical name: | Oleosin |
| MW(SDS-PAGE): | 17 kDa |
| Allergenicity: | Pediatric food allergic subjects, 17 tested positive for IgE binding out of 26 subjects to natural and recombinant protein. There were 5 negative controls. IgE binding was with 1D and 2D immunoblots from oilbody extracts. Also 2 ug of recombinant protein could inhibit IgE binding. Test subjects, 30 of 30 tested positive by SPT to hazelnut. 18 of 30 subjects were positive by in vivo challenge to whole seed. |
| Allergenicity reference: | PubMed:34146442 |
| Route of allergen exposure: | Food |
| Date Created: | 07-07-2019 |
| Last Updated: | 2023-07-17 18:17:06 |
| Submitter Info: | |
| Name: | Maria Gabriella Giuffrida; Giovanna Monti |
| Institution: | CNR, ISPA; Regina Margherita Children |
| City: | Grugliasco, Italy; Turin, Italy |
| Email: | gabriella.giuffrida@ispa.cnr.it; giovanna.monti@email.it |
| Submission Date: | 2019-06-06 |
Comments
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Cor a 15.0101 | MK737923 | QEM21451 | C0HM28 |
I first put this in Cor a 12.02. The submitter objected and in reviewing oleosins, I realized that it is the irregular Amino and Carboxy ends that are the unique sequences. The middle sequence is conserved as a trans-lipid section in oleosins. The IgE binding must be in the ends.