ALLERGEN NOMENCLATURE
WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Cor a 15
Lineage: Source: Plantae Magnoliopsida
Order: Fagales
Species: Corylus avellana (Hazelnut)
Biochemical name:Oleosin
MW(SDS-PAGE):17 kDa
Allergenicity:Pediatric food allergic subjects, 17 tested positive for IgE binding out of 26 subjects to natural and recombinant protein. There were 5 negative controls. IgE binding was with 1D and 2D immunoblots from oilbody extracts. Also 2 ug of recombinant protein could inhibit IgE binding. Test subjects, 30 of 30 tested positive by SPT to hazelnut. 18 of 30 subjects were positive by in vivo challenge to whole seed. Data was presented at EAACI Congress in Munich DE in 2018, Allergy, 73:105 page 180, abstract 0308.
Route of allergen exposure:Food
Date Created:07-07-2019
Last Updated:2019-08-03 00:19:06
Submitter Info:
Name:Maria Gabriella Giuffrida; Giovanna Monti
Institution:CNR, ISPA; Regina Margherita Children
City:Grugliasco, Italy; Turin, Italy
Email:gabriella.giuffrida@ispa.cnr.it; giovanna.monti@email.it
Submission Date:2019-06-06

Comments

Posted: 07 Jul 2019

I first put this in Cor a 12.02. The submitter objected and in reviewing oleosins, I realized that it is the irregular Amino and Carboxy ends that are the unique sequences. The middle sequence is conserved as a trans-lipid section in oleosins. The IgE binding must be in the ends.

Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Cor a 15.0101MK737923