Allergen Details:
| Allergen name: | Cor a 15 |
|---|---|
| Lineage: |
Source: Plantae Magnoliopsida Order: Fagales Species: Corylus avellana (Hazelnut) |
| Biochemical name: | Oleosin |
| MW(SDS-PAGE): | 17 kDa |
| Allergenicity: | Pediatric food allergic subjects, 17 tested positive for IgE binding out of 26 subjects to natural and recombinant protein. There were 5 negative controls. IgE binding was with 1D and 2D immunoblots from oilbody extracts. Also 2 ug of recombinant protein could inhibit IgE binding. Test subjects, 30 of 30 tested positive by SPT to hazelnut. 18 of 30 subjects were positive by in vivo challenge to whole seed. Data was presented at EAACI Congress in Munich DE in 2018, Allergy, 73:105 page 180, abstract 0308. |
| Route of allergen exposure: | Food |
| Date Created: | 07-07-2019 |
| Last Updated: | 2019-08-03 00:19:06 |
| Submitter Info: | |
| Name: | Maria Gabriella Giuffrida; Giovanna Monti |
| Institution: | CNR, ISPA; Regina Margherita Children |
| City: | Grugliasco, Italy; Turin, Italy |
| Email: | gabriella.giuffrida@ispa.cnr.it; giovanna.monti@email.it |
| Submission Date: | 2019-06-06 |
Comments
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Cor a 15.0101 | MK737923 |
I first put this in Cor a 12.02. The submitter objected and in reviewing oleosins, I realized that it is the irregular Amino and Carboxy ends that are the unique sequences. The middle sequence is conserved as a trans-lipid section in oleosins. The IgE binding must be in the ends.