Allergen Details:
| Allergen name: | Fag e 4 |
|---|---|
| Allergen source: |
Major taxonomic group: Plantae Eudikotyledons Order: Caryophyllales Species: Fagopyrum esculentum (Common buckwheat) NCBI Taxomony ID: 3617 |
| Obsolete name: | Fa-AMP |
| Biochemical name: | Hevein-like antimicrobial peptide |
| MW(SDS-PAGE): | 3.9 kDa |
| Allergenicity: | Seven serum donors with convincing case histories of buckwheat allergy were tested. Food challenges were performed with positive outcome in 3/7 patients whereas not done in 4/7. SPTs were performed using total extract of the source as well as for oral food challenges. Serum derived IgE to native proteins from the extract was tested by western blot (6/7 positive). 5/7 samples were positive to purified Fag e 4 in ELISA. Natural exposure is by ingestion. Controls were performed with sera from 5 healthy donors, and 28 sera from atopic controls. |
| Allergenicity reference: | PubMed:29171912 |
| Route of allergen exposure: | Food |
| Date Created: | 21-04-2017 |
| Last Updated: | 2023-03-15 17:35:43 |
| Submitter Info: | |
| Name: | Karin Hoffmann-Sommergruber |
| Institution: | Medical University of Vienna |
| City: | Vienna, Austria |
| Email: | karin.hoffmann@muv.ac.at |
| Submission Date: | 2017-02-13 |
Comments
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Fag e 4.0101 | P0DKH7 | |||
| Fag e 4.0102 | P0DKH8 |
Fag e 4 used as parent number since other members of Caryophyllales have Oleosin-like protein as #1, and #2 and #3 are already used.