Allergen Details:
| Allergen name: | Aed a 6 |
|---|---|
| Allergen source: |
Major taxonomic group: Animalia Arthropoda Order: Diptera Species: Aedes aegypti (Yellow fever mosquito) NCBI Taxomony ID: 7159 |
| Biochemical name: | Porin3 |
| MW(SDS-PAGE): | 30.7 kDa |
| Allergenicity: | Case history of mosquito allergy (bites and/or inhalation of insect parts) from subjects living in the Caribbean island of Martinique with asthma and/or rhinitis and specific IgE to mosquito extract. Proteins of defatted, freeze dried mosquitoes, with proteins separated on 2D gels and immunoblotted with six individual sera Abstract presented at EAACI Barcelona, 2015. IgE binding spots were identified by mass LC/MS-MS of trypsinized gel spots. Porin3 bound IgE from 2 of 6 subjects. |
| Route of allergen exposure: | Airway |
| Date Created: | 16-12-2015 |
| Last Updated: | 2019-07-22 17:21:30 |
| Submitter Info: | |
| Name: | Jose F. Cantillo |
| Institution: | Instituto de Investigaciones Inmunologicas-Universidad de Cartagena |
| City: | Cartagena, Colombia |
| Email: | josefcantillo@gmail.com |
| Submission Date: | 2015-12-16 |
Comments
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Aed a 6.0101 | XM_001654093.1 | XP_001654143.1 | Q1HR57 |
New paper by Cantillo, used whole body freeze dried adult mosquito insects, used 2D gel immunoblots to show IgE binding. However, other papers show these Porin proteins are membrane bound in the digestive tract and airway of mosquitoes. NOT a salivary protein.
22 July 2019
Presentation of new allergens of Aedes aegypti (Aed a 4-8) in oral abstract session of the EAACI, Barcelona, Spain, 2015; abstract in Allergy, v70, abstr # 133. The work done for the identification and characterization of this allergen were made by:
Jose F. Cantillo, Leonardo Puerta and Enrique Fernandez-Caldas.