Allergen Details:
| Allergen name: | Ani s 13 |
|---|---|
| Allergen source: |
Major taxonomic group: Animalia Nematoda Order: Ascaridida Species: Anisakis simplex (Herring worm) NCBI Taxomony ID: 6269 |
| Biochemical name: | Hemoglobin |
| MW(SDS-PAGE): | 37 kDa |
| Allergenicity: | Twenty eight of 44 case-history positive subjects diagnosed with Gastro-allergic Anisakiasis or Anisakis sensitization associated chronic urticaria, had demonstrable IgE binding to the protein by hemoglobin-specific capture ELISA. |
| Allergenicity reference: | PubMed:25683373 |
| Route of allergen exposure: | Food |
| Date Created: | 21-07-2014 |
| Last Updated: | 2019-07-03 18:54:30 |
| Submitter Info: | |
| Name: | Juan Gonzalez-Fernandez |
| Institution: | Universidad Complutense de Madrid |
| City: | Madrid, Spain |
| Email: | quintas_copo@hotmail.com |
| Submission Date: | 2014-07-21 |
Comments
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Ani s 13.0101 | JX860676.1 | AFY98826 | K9USK2 |
Manuscript now available as pre-print,available online. PUBMID 25683373.
Submitted pre-publication. Publication of the antibody used to capture the hemoglobin is: Nieuwenhuizen NE, Meter JM, Horsnell WG, Hoving JC, Fick L et al. (2013) A cross-reactive monoclonal antibody to Nematode Haemoglobin Enhances Protective Immune Responses to Nippostrongylus brasiliensis. PLoS Negl Trop Dis 7(8):e2395. Sequence confirmed 93% with MS/MS. Also, nucleotide sequence determined. PCR cloned Sequence reference 24009787 Lopata et al.
Allergenicity reference as a Congress abstract. Cuellar C, Gonzalez-Fernandez J, Rodero M, Valls A, de Frutos C, Daschner A, Nieuwenhuizen N. La Hemoglobina de Anisakis simplex: factores que influyen sobre su reconcimiento. 2013. XVIII Congreso de la Sociedad Espanola de Parasitologia.