Allergen Details:
| Allergen name: | Pla a 3 |
|---|---|
| Allergen source: |
Major taxonomic group: Plantae basal Mesangiosperms Order: Proteales Species: Platanus acerifolia (London plane tree) NCBI Taxomony ID: 140101 |
| Biochemical name: | Non-specific lipid transfer protein 1 |
| MW(SDS-PAGE): | 10 kDa |
| Allergenicity: | Of 58 plane pollen allergic patients, 45% showed IgE binding to purified nPla a 3 in immunoblot. The rates of sensitization to Pla a 3 in plane allergic patients with and without peach allergy were 61% and 18%, respectively. |
| Allergenicity reference: | PubMed:17250699 |
| Route of allergen exposure: | Airway |
| Date Created: | 05-11-2006 |
| Last Updated: | 2019-09-05 23:58:53 |
| Submitter Info: | |
| Name: | Iris Lauer |
| Institution: | Department of Allergology, Paul-Ehrlich-Institut |
| City: | Langen, Germany |
| Email: | lauir@pei.de |
| Submission Date: | 2015-05-06 |
Comments
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Pla a 3.0101 | KR139936 | ALF39466 | A0A0N9E6M0 | |
| Pla a 3.0201 | KR092033 | ALF00099 | Q14K71 |
on 5/6/2015 Andrea Wangorsch. of PEI sent a note and a submission to GenBank for a mature full length sequence of Pla a 3.0101, but there is a one-aa difference (last aa of 25) from the N-term sequencing in the I. Lauer paper for 3.0101, compared to the cDNA.In addition, Thermo Fisher has performed LC-MSMS on pollen sample and confirmed that the mature 3.0101 protein should NOT have the second V (position 25). Therefore we are replacing the N-terminal peptide sequence with the full-mature sequence determined by cDNA sequencing.
The original entry was ~ 2010, but the date of 6 May, 2015 is used for the updated cDNA sequence.
Sequence and data for Pla a 3.0201 was submitted 2015-05-06 REG