Allergen Details:
| Allergen name: | Phl p 5 |
|---|---|
| Allergen source: |
Major taxonomic group: Plantae Liliopsida (monocots) Order: Poales Species: Phleum pratense (Timothy) NCBI Taxomony ID: 15957 |
| MW(SDS-PAGE): | 32 kDa |
| Allergenicity: | 95% of grass pollen-allergic patients (98 tested) showed IgE binding to Phl p 5 in immunoblot of pollen extract; 97/98 subjects showed IgE binding to rPhl p 5 on nitrocellulose filters. - all patients (11) with positive skin prick test responses to grass pollen allergens reacted to the C-terminal, and 73% react to the N-terminal peptide of Phl p 5a. - Purified rPhl p 5 elicited dose-dependent basophil histamine release in 1 patient tested, and immediate type skin reactions in 4 patients test |
| Allergenicity reference: | PubMed:1597349 |
| Route of allergen exposure: | Airway |
| Date Created: | 13-02-2003 |
| Last Updated: | 2019-09-05 22:45:36 |
| Submitter Info: | |
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Comments
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Phl p 5.0101 | X74735 | CAA52753 | Q40960 | 2M64 |
| Phl p 5.0102 | X70942 | CAA50281 | Q40962 | |
| Phl p 5.0103 | AF069470 | AAC25994 | O81341 | |
| Phl p 5.0104 | Z82986 | CAB05372 | P93467 | |
| Phl p 5.0105 | AF061066 | AAC16525 | O65318 | |
| Phl p 5.0106 | AF061067 | AAC16526 | O65319 | |
| Phl p 5.0107 | AF061068 | AAC16527 | O65320 | |
| Phl p 5.0108 | AF061069 | AAC16528 | O65321 | |
| Phl p 5.0109 | AJ555152 | CAD87529 | Q84UI2 | |
| Phl p 5.0201 | Z27083 | CAA81609 | Q40963 | 1L3P |
| Phl p 5.0202 | Z82985 | CAB05371 | P93466 | |
| Phl p 5.0203 | AF069471 | AAC25995 | O81342 | |
| Phl p 5.0204 | ||||
| Phl p 5.0205 | ||||
| Phl p 5.0206 | AF069473 | AAC25997 | O81343 | |
| Phl p 5.0207 | AF069474 | AAC25998 | O81344 |