WHO/IUIS Allergen Nomenclature Sub-Committee

Financial contribution from IUIS, EAACI, and AAAAI organizations

Member Login

Allergen Details:

Allergen name: Ory s 12
Allergen source: Major taxonomic group: Plantae Liliopsida
Order: Poales
Species: Oryza sativa (Rice)
Biochemical name:Profilin A
Allergenicity:IgE binding was tested to extracts and recombinant proteins from Hirano et al., 2013, J Biochem. The 10 subjects sera from Japan were tested positive to beta expansin and polycalcin extensin and weakly to polygalacturonase, almost negative to profilin. The clones were expressed as fusion proteins with thioredoxin and the three subjects with IgE binding to fused recombinant protein were nearly all due to thioredoxin. Those without IgE to thioredoxin did not bind. The significance of the three binding to fused thioredoxin and profilin is therefore not clear.
Allergenicity reference:PubMed:23694780
Route of allergen exposure:Airway
Date Created:25-03-2003
Last Updated:2019-09-05 00:46:55
Submitter Info:
Submission Date:


Posted: 05 Jan 2021

Not very clear evidence that profilin from rice pollen is an allergen, based on review of the Hirano paper. 1/5/2021 REG.

Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Ory s 12.0101AF310253AAG32056Q9FUD1