Allergen Details:
| Allergen name: | Jug r 2 |
|---|---|
| Allergen source: |
Major taxonomic group: Plantae Eudikotyledons Order: Fagales Species: Juglans regia (English walnut) NCBI Taxomony ID: 51240 |
| Biochemical name: | Vicilin (7S globulin) seed storage protein |
| MW(SDS-PAGE): | 44 kDa |
| Allergenicity: | A recombinant GST-fusion protein of full-length Jug r 2.0101 was shown to bind serum IgE from 9 of 15 patients tested |
| Allergenicity reference: | PubMed:10589017 |
| Route of allergen exposure: | Food |
| Date Created: | 27-03-2003 |
| Last Updated: | 2022-06-22 19:03:40 |
| Submitter Info: | |
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Comments
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Jug r 2.0101 | AF066055 | AAF18269 | Q9SEW4 | |
| Jug r 2.0101 (1-173) | AF066055 (1-519) | AAF18269 (1-173) | Q9SEW4 (1-173) | |
| Jug r 2.0102 | XM_018956626 | XP_018812171 | A0A2I4DYF1 | |
| Jug r 2.0102 (27-367) | XP_018812171 (27-367) | A0A2I4DYF1 (27-367) | ||
| Jug r 2.0102 (368-789) | XP_018812171 (368-789) | A0A2I4DYF1 (368-789) |
The full length genomic sequence predicts a longer protein XP_018812170 of 95 kDa, and the allergen identified as Jug r 2.0101 starts at AA position 197. Nesbit and Maleki 2019 JACI 143 in an abstract, identified an N-terminal 171 AA portion of that molecule as an IgE binding stable independent protein fragment