Allergen Details:
| Allergen name: | Cand b 2 |
|---|---|
| Allergen source: |
Major taxonomic group: Fungi Ascomycota Order: Saccharomycetales Species: Candida boidinii (Yeast) NCBI Taxomony ID: 5477 |
| Biochemical name: | Peroxisomal membrane protein A |
| MW(SDS-PAGE): | 20 kDa |
| Allergenicity: | 89 patients sensitized to A. fumigatus displayed significantly higher levels of rCand b 2-specific IgE in their serum (mean value: 100 EU/ml; p LESSTHAN 0.005) than 11 control individuals without a history of atopy. |
| Allergenicity reference: | PubMed:9412580 |
| Route of allergen exposure: | Airway |
| Date Created: | 01-09-2003 |
| Last Updated: | 2019-07-20 07:53:32 |
| Submitter Info: | |
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Comments
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Cand b 2.0101 | J04984 | AAA34357 | P14292 |
The allergenicity or IgE binding described in the Hemmann paper (1997) used sera from asthmatic subjects with high IgE to Aspergillus fumigatus Asp f 3. Binding of the 89 subjects to the peroxisomal proteins of Candida boidinii was markedly less (~ 1/2 log greater than control sera for C boidinii), while 2 log higher in binding to Asp f 3. Additionally, the cross-reactive inhibition by Cand b 2 was only 1/100 to 1/1000 compared to Asp f 3 inhibition of binding to Asp f 3.