ALLERGEN NOMENCLATURE
IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Cand b 2
Lineage: Source: Fungi Ascomycota
Order: Saccharomycetales
Species: Candida boidinii (Yeast)
Biochemical name:Peroxisomal membrane protein A
MW(SDS-PAGE):20
Allergenicity:89 patients sensitized to A. fumigatus displayed significantly higher levels of rCand b 2-specific IgE in their serum (mean value: 100 EU/ml; p LESSTHAN 0.005) than 11 control individuals without a history of atopy.
Allergenicity ref.:9412580
Food allergen:No
Date Created:2010-04-29 16:57:55
Last Updated:2010-04-29 16:57:55
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Comments

Posted: 29 Oct 2014

The allergenicity or IgE binding described in the Hemmann paper (1997) used sera from asthmatic subjects with high IgE to Aspergillus fumigatus Asp f 3. Binding of the 89 subjects to the peroxisomal proteins of Candida boidinii was markedly less (~ 1/2 log greater than control sera for C boidinii), while 2 log higher in binding to Asp f 3. Additionally, the cross-reactive inhibition by Cand b 2 was only 1/100 to 1/1000 compared to Asp f 3 inhibition of binding to Asp f 3.

Table of IsoAllergens:

Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Cand b 2.0101J04984AAA34357P14292