Allergen Details:
| Allergen name: | Cand a 1 |
|---|---|
| Allergen source: |
Major taxonomic group: Fungi Ascomycota Order: Saccharomycetales Species: Candida albicans (Common yeast) NCBI Taxomony ID: 5476 |
| Biochemical name: | Alcohol dehydrogenase |
| MW(SDS-PAGE): | 40 kDa |
| Allergenicity: | Of 30 asthmatic patients with a positive skin test and RAST to C.albicans, 23 (77%) showed serum IgE binding to a 40 kD component on an immunoblot of C.albicans extract. - This 40 kD protein was cloned and identified as Cand a 1. IgE binding to both natural and rCand a 1 was demonstrated on immunoblot and in ELISA (medline 92136159). |
| Allergenicity reference: | PubMed:2665907 |
| Route of allergen exposure: | Airway |
| Date Created: | 01-09-2003 |
| Last Updated: | 2019-07-20 07:50:40 |
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Comments
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Cand a 1.0101 | X81694 | CAA57342 | P43067 |
Note the allegenicity in Shen et al., 1989, Clin Exp Allergy used immunoblots of extracts to with 30 allergic sera to identify 77% + IgE binding to a 40 kDa protein (Fig 2). The sequencing paper (Shen et al., 1991, Clin Exp Allergy) shows partial cloned sequence of Cand a 1 that matches a portion of their 350 aa sequence in locus CAA57342.1. So evidence is not against purified protein. REG