Allergen Details:
| Allergen name: | Act d 7 |
|---|---|
| Allergen source: |
Major taxonomic group: Plantae Eudikotyledons Order: Ericales Species: Actinidia deliciosa (Green kiwi fruit) NCBI Taxomony ID: 3627 |
| Biochemical name: | Pectin methylesterase |
| MW(SDS-PAGE): | 50 kDa |
| Allergenicity: | IgE prevalence: 32% of 50 kiwi allergic patients in immunoblot |
| Route of allergen exposure: | Food |
| Date Created: | 18-12-2007 |
| Last Updated: | 2019-06-28 07:24:00 |
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Comments
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Act d 7.0101 | P85076 | P85076 |
According to the authors Ciardiello et al., 2008, the protein has 4 glycans, some of them are complex N-linked. The deduced MW based on AA sequence is 35 kDa, but tested MW is 50 kDa due to glycosylation. The complex glycan analysis indicates it they are targets of IgE binding for some subjects. Bublin et al., Clin Exp Allergy, 2011 41:129-136 used natural fruit Act d 7 in IgE binding tests that demonstrated IgE binding in 53 of 237 kiwi allergic sera and 53 of 198 kiwi tolerant subjects. REG