ALLERGEN NOMENCLATURE
IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Bet v 1
Lineage: Source: Plantae Magnoliopsida
Order: Fagales
Species: Betula verrucosa (Betula pendula) (European white birch)
Biochemical name:Pathogenesis-related protein, PR-10, Bet v 1 family member
MW(SDS-PAGE):17
Allergenicity:Bet v 1 is responsible for IgE binding in more than 95% of birch pollen allergic patients
Allergenicity ref.:6886253
Food allergen:No
Date Created:2010-04-29 16:57:55
Last Updated:2013-06-04 10:29:35
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Comments

Posted: 26 Apr 2013

At its meeting in February 2013, the IUIS Allergen Nomenclature Sub-Committee decided to update the nomenclature of Bet v 1 isoallergens based on the following principles: 1. The database should contain only Bet v 1 sequences whose expression in pollen has been proved at least on the mRNA level. 2. Similar sequences are grouped as variants of an isoallergen if they show >90% sequence identity. 3. Different variant numbers are assigned only to variants with different protein sequences. Nucleotide sequences differing only be silent mutations are not distinguished by the allergen nomenclature. As a consequence, the following entries were deleted: Bet v 1.11-Bet v 1.13 and Bet v 1.15-Bet v 1.23. The following variants were merged into a single entry: Bet v 1.0101/0102/0103, Bet v 1.0401/0402 (now Bet v 1.0102), Bet v 1.0601/0602 (now Bet v 1.0104) and Bet v 1.1401/1402 (now Bet v 1.0204). The following entries were classified as variants of Bet v 1.01: Bet v 1.01, Bet v 1.04-Bet v 1.08, Bet v 1.10 and Bet v 1.24-Bet v 1.30. The following entries were classified as variants of Bet v 1.02: Bet v 1.02, Bet v 1.03, Bet v 1.09 and Bet v 1.14.

Table of IsoAllergens:

Isoallergen and variants GenBank Nucleotide UniProt PDB
Bet v 1.0101X15877 Z80098 Z80099P154944A88
Bet v 1.0102X77266 X77270P43177 
Bet v 1.0103X77267P43178 
Bet v 1.0104X77268 X77274P43179 
Bet v 1.0105X77269P43180 
Bet v 1.0106X77271P431834A8U
Bet v 1.0107X77273P431851FM4
Bet v 1.0108Z80100Q96365 
Bet v 1.0109Z80101Q96366 
Bet v 1.0110Z80102Q96367 
Bet v 1.0111Z80103Q96368 
Bet v 1.0112Z80104P15494 (variant F63L)1BV1 1BTV
Bet v 1.0113Z80105Q96370 
Bet v 1.0114Z80106Q96371 
Bet v 1.0201X77200P45431 
Bet v 1.0202X77265P43176 
Bet v 1.0203X77272P43184 
Bet v 1.0204X81972 X82028P43186