Allergen Details:
| Allergen name: | Cry j 3 |
|---|---|
| Allergen source: |
Major taxonomic group: Plantae Pinopsida Order: Cupressales Species: Cryptomeria japonica (Sugi, Japanese cedar) NCBI Taxomony ID: 3369 |
| Biochemical name: | Thaumatin-like protein (pathogenesis-related protein PR-5) |
| MW(SDS-PAGE): | 27 kDa |
| Allergenicity: | One hundred patients with allergy to Japanese cedar pollen, diagnosed based on typical symptoms and specific IgE (ImmunoCAP class >= 2), were tested. Of those, 27 sera contained IgE specific to highly purified natural Cry j 3. The allergen could activate basophils from a Cry j 3-sensitized patient in a histamine release assay. |
| Allergenicity reference: | PubMed:17441795 |
| Route of allergen exposure: | Airway |
| Date Created: | 2023-12-14 |
| Last Updated: | 2023-12-14 14:54:52 |
| Submitter Info: | |
| Name: | Masahiro Sakaguchi |
| Institution: | Institute of Tokyo Environmental Allergy |
| City: | Tokyo, Japan |
| Email: | sakaguchi@itea.jp |
| Submission Date: | 2023-09-14 |
Comments
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|
The N-terminal 13 residues of nCry j 3 were determined by Edman sequencing (see allergenicity reference). This sequence corresponds to "Cry j 3.8" isolated from pollen mRNA by the submitter (nucleotide acc. no. AB254807) but also to 8 other sequences identified in the Cryptomeria japonica genome with 95-96% identical amino acid sequences. Hence, no isoallergen record was added to this entry.
Christian Radauer, science co-chair