ALLERGEN NOMENCLATURE
WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Art si 14
Allergen source: Major taxonomic group: Plantae Magnoliopsida
Order: Asterales
Species: Artemisia sieversiana (Sieversian wormwood)
Biochemical name:Fructose bisphosphate aldolase
MW(SDS-PAGE):38 kDa
Allergenicity:In an IgE dot-blot, natural Art si 14 as well as recombinant Art si 14.0101, produced in E. coli, bound IgE from 10 of 20 sera (50%) from Artemisia pollen allergic patients (symptoms: allergic rhinitis and/or asthma; ImmunoCAP class >= 3 with A. vulgaris ImmunoCAP). Nine of the ten dot-blot-positive sera also bound both allergens in IgE Western blot. In an IgE-ELISA, 50 of 87 sera (57%) from Artemisia pollen allergic patients had IgE to rArt si 14.0101. IgE ELISA inhibitions with a pool of Art si 14-sensitized sera showed partial inhibition of IgE binding to A. sieversiana pollen extract by natural and recombinant Art si 14 as well as a high extent of cross-reactivity with Art an 14. In a BAT assay, 3 of 3 Art si 14-sensitized patients reacted with rArt si 14.
Route of allergen exposure:Airway
Date Created:2022-10-17
Last Updated:2022-10-17 17:08:37
Submitter Info:
Name:Ji-Fu Wei, Jin-Lyu Sun
Institution:Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University; State Key Laboratory of Complex Severe and Rare Diseases, PUMCH, CAMS
City:Nanjing, China and Beijing, China
Email:weijifu@hotmail.com, sunjinlv@pumch.cn
Submission Date:2022-10-07

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Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Art si 14.0101MW790924UUH54329 7EFS