Allergen Details:
| Allergen name: | Pla a 6 |
|---|---|
| Allergen source: |
Major taxonomic group: Plantae basal Mesangiosperms Order: Proteales Species: Platanus acerifolia (London plane tree) NCBI Taxomony ID: 140101 |
| Biochemical name: | Enolase |
| MW(SDS-PAGE): | 48 kDa |
| Allergenicity: | Thirty-seven P. acerifolia-sensitized patients with allergic rhinitis in spring were tested. All has positive SPT and sIgE (measured by ImmunoCAP) to plane tree pollen extract. Of those 12 (32%) had serum IgE to natural Pla a 6, measured by immunoblot. Eleven of the 12 nPla a 6-reactive sera also recognized recombinant Pla a 6 in immunoblot. In a BAT assay, basophils from 4 of 5 Pla a 6-sensitized patients could be stimulated by nPla a 6. |
| Allergenicity reference: | PubMed:36252468 |
| Route of allergen exposure: | Airway |
| Date Created: | 2022-08-22 |
| Last Updated: | 2023-03-31 13:17:17 |
| Submitter Info: | |
| Name: | Jin-Lyu Sun, Ji-Fu Wei |
| Institution: | State Key Laboratory of Complex Severe and Rare Diseases, PUMCH, CAMS; Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University |
| City: | Beijing, China and Nanjing, China |
| Email: | sunjinlv@pumch.cn, weijifu@hotmail.com |
| Submission Date: | 2022-08-05 |
Comments
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Pla a 6.0101 | OK323202 | UYQ90943 |