Allergen Details:
| Allergen name: | Man i 4 |
|---|---|
| Allergen source: |
Major taxonomic group: Plantae Eudikotyledons Order: Sapindales Species: Mangifera indica (Mango) |
| Biochemical name: | Profilin |
| MW(SDS-PAGE): | 14 kDa |
| Allergenicity: | Sixty-one sera from mango-allergic patients (as defined by history) were tested by IgE-ELISA. Of those, 24 (39%) had IgE to rMal i 4.0101. In the subgroup of 26 patients with mango ImmunoCAP > 0.35 kU/L, 16 (62%) were sensitized to Man i 4.0101. IgE-levels to Man I 4.0101 correlated with IgE to Art an 4.0101 (profilin from sweet wormwood pollen). 12 sera from mango allegric patients who were sensitized to Man i 4.0101 were also tested with rMan i 4.0102 by IgE ELISA. All sera also reacted to Man i 4.0102, albeit with significantly lower signals. |
| Allergenicity reference: | PubMed:36724175 |
| Route of allergen exposure: | Food |
| Date Created: | 2022/02/23 |
| Last Updated: | 2023-04-03 18:37:02 |
| Submitter Info: | |
| Name: | Zhong-Shan Gao; Lan Zhao |
| Institution: | Zhejiang University, College of Agriculture and Biotechnology |
| City: | Hangzhou, China |
| Email: | gaozhongshan@zju.edu.cn; 21716040@zju.edu.cn |
| Submission Date: | 2022-01-29 |
Comments
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Man i 4.0101 | OK136959 | UYO79700 | ||
| Man i 4.0102 | OK136960 | UYO79701 |