Allergen Details:
| Allergen name: | Can s 4 |
|---|---|
| Allergen source: |
Major taxonomic group: Plantae Eudikotyledons Order: Rosales Species: Cannabis sativa (Indian hemp) NCBI Taxomony ID: 3483 |
| Biochemical name: | Oxygen evolving Enhancer Protein 2 |
| MW(SDS-PAGE): | 27.3 kDa |
| Allergenicity: | A total of 118 subjects, 113 with immediate symptoms upon exposure by inhalation (113 and two upon ingestion to cannabis, 30 healthy controls adn 45 with individual pollen or nsLTP sensitization were tested for IgE binding. 8 bound to the recombinant protein by CBA test. Three were positive by basophil activation. Not published yet |
| Route of allergen exposure: | Airway |
| Date Created: | 2020/2/27 |
| Last Updated: | 2020-03-02 17:14:35 |
| Submitter Info: | |
| Name: | Hans-Peter Rihs |
| Institution: | IPA, Molecular Genetics |
| City: | Bochum, Germany |
| Email: | rihs@ipa-dguv.de |
| Submission Date: | 2019-09-30 |
Comments
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Can s 4.0101 | XM_030626708.1 | XP_030482568.1 |
113 subjects reacted immediately after inhalation. Two subjects reacted following ingestion based on submitter comments. This is a green tissue protein